As hCG stimulates the testicles to produce testosterone and sperm, the testicles grow in size over time. LH stimulates Leydig cells in the testicles, which results in the production of testosterone. HCG may also help improve sexual function in MAABs who don’t experience improvement while on testosterone. Injections of hCG are also sometimes used as an alternative to testosterone products in MAABs with testosterone deficiency. Pregnancy tests check hCG levels in the urine or blood to determine if a person is pregnant or not. In males assigned at birth (MAABs), they can treat a type of hypogonadism.
Whether this accounts for the lingering symptoms some men describe is still an area of ongoing clinical study, but it is a reasonable and legitimate concern. The testes produce not just testosterone but also other androgens and hormones including estradiol, progesterone, and factors that influence mood and neurological well-being. Sperm production, which depends on the same signaling pathway, typically declines and can stop altogether during testosterone-only therapy. The testes are not just testosterone factories; they produce a range of hormones and signaling molecules, and keeping them active has value beyond the testosterone number alone. This happens because the testes respond to the HCG signal by producing more testosterone naturally, along with other hormones and compounds that the testes generate during normal function. Energy levels can improve, libido may increase, and mood can stabilize. So do men who feel hesitant about committing to exogenous testosterone and want to explore options that work with their existing physiology.
And as with TRT, hCG can increase your oestrogen levels (as T goes up, some of it is converted into oestrogen). They will consider your current hormone levels, whether you’re planning to have children anytime soon, and your medical history when deciding which starting dose is best. Aside from boosting testosterone, they can preserve your fertility. With secondary hypogonadism (also called hypogonadotropic hypogonadism, or HH), the brain doesn’t make enough LH, so testosterone drops significantly. But for men who have low T due to secondary hypogonadism—when there’s an issue with how the brain signals to the testes—hCG can boost testosterone production.
However, such an increase was not noted in another randomized placebo-controlled study on testosterone treatment in frail older men . A meta-analyses of testosterone replacement therapy clinical trials showed no increase in cardiovascular adverse events . Further large scale longitudinal studies are needed to ascertain the effects of testosterone replacement therapy in men with OSA. Hypogonadal men with moderate to severe obstructive sleep apnea (OSA) are at an increased theoretical risk for exacerbation of OSA with testosterone replacement therapy, particularly if supra-physiologic doses of testosterone are used 1,55,84-86. The most common adverse effect of testosterone replacement therapy is increase in hemoglobin, hematocrit and red cell indices . Common adverse events of testosterone replacement therapy include development of acne and increased oiliness of skin because of the androgenic effects on sebaceous gland.
Median duration of therapy was 8 months (SD 5 months). The hormone hCG is an FDA-approved medication for treating specific conditions in people assigned both male and female at birth. However, it shouldn’t be used by people assigned male at birth with prostate cancer, certain brain cancers, or uncontrolled thyroid disease. Testosterone levels above 300 ng/dL are widely considered normal.
For these men, treatment of the primary condition by lifestyle modifications and disease-specific medications should be used before testosterone replacement. Patients with a history of chronic opiate use and who present with symptoms of hypogonadism should be evaluated. Patients with a normal free or bioavailable testosterone with low or low normal total testosterone and normal LH and FSH do not warrant treatment with testosterone. When obese men present with symptoms of hypogonadism, lifestyle changes (e.g., caloric reduction and exercise) should be advised. Neither of these classes of drugs is approved by the FDA for treatment of male hypogonadism. The higher LH levels stimulate the production of endogenous testosterone in men with residual hypothalamic-pituitary function, for example, aging and obesity . It should be noted that the sperm concentration does not need to be increased to the adult reference range before men with hypogonadotropic hypogonadism become fertile .

Gender: Female

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